Only recently has the pharmacologic activity of compounds isolated from the Pichuberry® been demonstrated. Intense background research on this fruit leads to the fact that the Pichuberry® has a healthy mineral and nutritional composition that surpasses several conventional and exotic fruits. This composition is currently catching the attention of scientists throughout the world.
Recent research suggests that the Pichuberry® contains Withanolides. Withanolides are a group of compounds that have shown to suppress cancer cells and act as antioxidants. Various withanolides and their biochemical mechanisms are currently being examined in cancer and liver studies as potential therapeutic agents against lung cancer and possibly a promising ingredient as a cancer-preventive functional food.
The Pichuberry® team is in collaboration with biochemical and nutritional research departments at the University of Arizona. This joint campaign focuses on essential minerals; micro minerals and trace minerals.
Aggarwal, B., Ichikawa, H., Jayaprakasam, B., Nair, M., Shishodia, T., Takada, Y. (2006).
Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-KB (NF-KB) activation and NF-KB-regulated gene expression. Molecular Cancer Therapeutics 5, no. 6.
Arun, M. & Asha, V. V. (2007).
Preliminary studies on antihepatotoxic effect of Physalis peruviana Linn (Solanaceae) against carbon tetrachloride induced acute liver injury in rats. Journal of Ethnopharmacology 111, no. 1, 110–14.
Fang, S. T., Liu, J. K., Li, B. (2012).
Ten new withanolides from Physalis peruviana. Steroids 77:36–44.
Fischer, G., Ebert, G., Ludders, P. (2000).
Provitamin A carotenoids, organic acids and ascorbic acid content of cape gooseberry (Physalis peruviana L.) ecotypes grown at two tropical altitudes. Acta Horticulturae 351:263–68.
Franco, L. A., Matiz, G. E., Calle, J., Pinzon, R., Ospina, L. F. (2007).
Actividad antinflamatoria de extractos y fracciones obtenidas de calices de Physalis peruviana L. Biomedica 47, no. 1, 51–60.
Martínez, W., Ospina, L. F., Granados, D., Delago, G. (2010).
In vitro studies on the relationship between the anti-inflammatory activity of Physalis peruviana extracts and the phagocytic process. Immunopharmacology and Immunotoxicology 32, no. 1, 63–73.
Puente, L. A., Pinto-Munoz, C. A., Castro, E. S., Cortes, M. (2011).
Physalis peruviana Linnaeus, the multiple properties of a highly functional fruit: A review.
Food Research International 44:1733–40.
Ramadan, M. F. & Morsel, J. T. (2003).
Goldenberry (Physalis peruviana L.). Journal of Agriculture and Food Chemistry 51, no. 4,969–74.
Ramadan, M. F. & Morsel, J. T. (2005).
Cape gooseberry: A golden fruit of golden future. Fruit Processing 15, no. 6, 396–400.
Rockenbach, I. I. et al. (2008).
Phenolic acids and antioxidant activity of Physalis peruviana L. fruit. Alimentos e Nutricao 19, no. 3, 271–76.
Wu, S. J. et al. (2005).
Antioxidant activities of Physalis peruviana. Biological Pharmaceutical Bulletin 28, no. 6, 963–66.
Yen, C. Y. et al. (2010).
4B-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest. BMC Cancer 10, no. 46.